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i, April 13, 1889.] BULKLEY: ARSENIC IN Differin And Acne Scars BULLOUS DISEASES OF THE SKIN. 403 ing on the scalp. On the chest Where To Buy Differin Gel and back nearly a quarter of the Epiduo Vs Differin surface was covered with new and old lesions, many being also on the extremities. Here and there could be seen bulliB, rounded on top, up to half an inch in diameter, with apparently clear contents, giving exit to serum and blood wlien ])unctured. Some of these were recorded as seated on healthy skin, with almost no surrounding indammation. Much of the eruption was composed of the crusted and ulcerated surfaces occupied by previous Differin Xp Gel Differin Gel Buy bullas, and, to render the diagnosis more obscure, they were largely arranged in circular and serpentine forms. She was extremely exhausted. Pulse, 120; temperature, 101-4° F. in the month. The bowels were acting twice daily. All other medication being discontinued, she was placed upon Fowler's solution, five drops every two hours, to be increased by a portion of a drop if necessary. She was also given a pill containing a third of a grain of opium, with two Buy Differin Gel 0.3 grains of quinine at bed-time, and locally carbolized oil (1 to 50) to be brushed over the lesions, some of which were very offensive. The results from the arsenic were even more than could Generic Differin Gel have been expected. Almost immediately the patient began to improve, and three weeks later the eruption had almost entirely vanished. The crusts fell off very shortly after beginning the arsenic, no new bull* formed, and healing progressed very rap- idly. Several months later she was given mild mixed treat- Differin Adapalene Cream 0.1 ment, witli a moderate quantity of iodide of potassium, but never again was she troubled with such an eruption. While arsenic proves of such signal advantage in the conditions already described in adults, its effects in some of the bullous eruptions in Differin Canada children are, if anything, even more marked in proper cases, and if given in efficient doses, as may be judged from the following cases : Case VII. — Eosalie B., aged ten years, was sent to me by Dr. J. Ackerman Coles, of Scotch Plains, N. J., May 25, 1887. The child then presented a typical herpes iris, and her condition was then as follows: The eruption was confined to the hands and forearms, feet, and lower legs, witli a few spots on the thighs and also about tlie Buy Differin Cream mouth and on the lips, likewise within the buccal cavity. The feet and lower legs were pretty thickly covered with new and old lesions, and on Order Differin Online the backs of the hands and wrists Differin Gel Generic some were most Coupon For Differin Gel typically characteristic, with a single bleb of some size and a circle of vesicles around, seated on a reddened base; in one or two instances there was a Differin Oily Skin second circle outside of this. In some places the blebs were of very considerable size, and were recorded as about an inch in diame- ter ; in other places they had ruptured, and the surface was either raw or covered with dried membrane or secretions. She suffered very considerably, more especially Differin Gel Online with the lesions on the lips and mouth, so that she could scarcely talk or take any nourishment. The history of the case was that in January, four months previous, she had a first attack, which lasted about a week. A second attack cam-e some few weeks later, and was even milder. The present attack had began three weeks previous to Differin Vs Epiduo her visit, and had increased steadily until the time she was seen. At the first visit she was given Fowler's solution, with an equal quantity of water, of which Buy Differin Gel Online she was to take five drops every two hours, increasing the dose gradually to ten drops if necessary and if there were no unpleasant symptoms. The next day. May 26th, there was already some improve- ment noted ; many of the lesions seemed less inflamed, and the child seemed more comfortable. A little castor-oil was then ordered, as there had been some constipation, and the drops were ordered to be increased. Five days later very marked im- provement was noted ; the bullae and vesicles were flattened, and most of the lesions were gone from the mouth, she having used also a lotion of borax, carbolic acid, and honey. A week later the eruption had disappeared, leaving only stains. She was then taking seven drops of the mixture, or three drojjs and a half of Fowler's solution every two hours. On two subsequent occasions, when the arsenic was neg- lected, she had a recurrence of the eruption, which was promptly checked by a return to the frequent doses of the arsenic. The remedy was then taken at longer intervals until finally it was discontinued, and she remained free from eruption. Case VIII. — Edward D., aged four years and a half, was brought to me in his mother's arms, October 29, 1887, so se- verely affected with herpes iris that he could not walk. The eruption began on the foot, four weeks previously, apparently from injury, the toe having been stepped on. The eru])tion had spread rapidly, with the development of new lesions, until, when first seen, much of the body was the seat of the disease, it being especially severe Differin For Acne Scars upon the Differin Lotion Coupon extremities. The hands and arms

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