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and ex[)iration ; and we have the well-known marbled order clomid online no prescription or carbonized organs which we see every day upon the post- mortem table. When the particles reach the lymph spaces, the fixed and free connective-tissue cells of the stroma join actively in the work. On section, we see in the alveolar septa, large numbers of round protoplasmic buy generic clomid cheap bodies, two or order clomid cheap three times the size of colorless blood-corpuscles, which are usually packed full of dark grains. A certain proportion is seen within the ordinary connective-tissue corpuscles, price of clomid in the uk and, in addition, there are, in variable numbers, ordinary leucocytes. But even these forces are insufficient to meet the constantly advancing stream of get clomid cheap dust particles. The destiny of those which escape the phagocytes in the alveolar stroma has been accurately followed in the investigations of Arnold and others.* En- tering the lymph clomid cheap stream, they are carried first into the lymph nodules, which, can you order clomid online in the lungs, surround the bronchi and blood-vessels, and a large number safe order clomid online become fixed in the cells of the follicular cords or are permanently imbedded in the stroma. As they pass along the lymph channels into the inter- lobular septa beneath the pleura, a still further number lodge and become permanently inclosed in the stroma cells, order clomid online canada and, finally, the remnant pass into the larger lymph chan- nels and ultimately lodge in the bronchial and tracheal glands. Here the lymph and stroma cells of the follicular cords dispose of them permanently. That this is effected in great part by the phagocytes is, I think, unquestioned. A scraping from any moderately pigmented lymph gland shows that the chief part of its carbon load is warehoused (so to speak) in protoplasm ; the granules lie for the most part im- bedded free in a connective-tissue matrix. Here the strug- gle is practically over, and though not a victory, yet the compromise which has been made is order clomid online the best which could possibly be effected. The sharp irritating particles have been placed in position in which they could do the least harm, and, though not expelled, have been safely imprisoned. Once in the lymph glands of the bronchi, it is thought they never reach the general circulation, but it has been shown of late years that, under certain circumstances, the * See a recent work of Fleiner's, Virchow's " Arehiv," Bd. cxii. April 13, 1889. 08LER: ON PHAOOCYTES. 395 carbon particles may pass the bronchial filters and spread far and price clomid australia wide throughout the system. Soyka's remarkable case, in which undoubted coal particles were found in the tissue of the spleen and of the liver, illustrates what reallv may occur. Weigert,* in particular, has called attention to the frequency with which, in the spleen and in the liver, carbonization of the connective tissue occurs. He states that it results whenever densely pigmented bronchial glands form close adhesion to the pulmonary veins, through purchase clomid cheap the walls of which the carbon particles pass and so reach the general circulation. I would not call the condition com- mon, but I have seen at least three instances at the Phila- delphia Hospital in which the irregularly distributed where is the best place to order clomid online pig- ment in the spleen and in the liver (in the latter chiefiy along the portal canals) was undoubtedly of extraneous, not of hiiemic origin. The steps in this process described may be followed in the lungs of any town dweller, but to see in perfection the remarkable activity of the pulmonary phagocytes, one must study the early stages of anthracosis, particularly in those exceptional cases which we can i order clomid online see occasionally when a miner has been killed by accident or dies of acute disease. It is not, 1 think, too much to say that the larger part of the pigment contained in the lungs, almost if not quite black, is inclosed in protoplasmic cells. Here, too, the invading particles are more formidable and not so readily dealt with; yet one frequently finds long, irregular bits completely en- circled by a film of protoplasm which the pliagocyte has stretched to the utmost, just as we may see an amoeba ex- tend along the whole length of one of the short, rod-like diatoms. I know of nothing which illustrates better the remarka- ble amoeboid properties of human protoplasm than a slide prepared from the scraping of such a lung, or of the black juice pressed therefrom. Scarcely a leucocyte can be seen which has not been at work, and many of the larger cells have the buy cheap clomid no rx protoplasm should order clomid online stuffed to the full w'ith carbon grains. Only in the work of the pond amoebfi;, preying among des- mids, diatoms, and algse, can we see such better illustrations of active work. There is, of course, this difference : that the amoeba eats generic clomid cheap to live, and, so far as I know, never loads its protoplasm with useless stuff. The body phagocytes take anything, never exercising selective powers. price clomid The par- ticles which gain entrance to the lungs may be far too large for a single phagocyte to attack successfully. I have sketches showing rod-like particles, the ends of which ap- where to buy clomid cheap pear inclosed in protoplasm of a dumb-bell shape ; while in one instance not only were the ends inclosed, but the cen- tral portion was completely enveloped by the third leucocyte.

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